Rifampicin appointed interior and intravenously, primarily as a means berkuleznogo protivotu-I series, as well as in the treatment of brucellosis and other diseases caused by microorganisms sensitive to rifampicin (pneumonia, pyelonephritis, osteomyelitis). Aminoglycosides are over sale mainly for severe infections caused Yellow Fever susceptible micro-organisms to aminoglycosides (Sepsis, peritonitis, urinary tract infections, pneumonia, wound and burn infection). Macrolides - erythromycin, clarithromycin, and azithromycin roksitromitsin (refers to azalides) act on the 50S subunit ribosome and the translocation break - the final step of protein synthesis in the ribosome-max bacteria. With infectious eye diseases (conjunctivitis, keratitis, blepharitis), chloramphenicol is used as eye drops or ointment. over sale side effects of antibiotics varied. For the discovery streptomycin - the first antibiotic effective for tuberculosis, Waksman (USA) in 1952 received the Nobel Prize. To macrolides are also midekamitsin (macroporous silicon) dzhosamitsin spiro-ching (rovamitsin). Practically not absorbed in the gastrointestinal tract, Gastric Ulcer here are administered parenterally. For example, tetracyclines, suppressing the normal gut can cause intestinal candidiasis. Used gentamicin with pneumonia, septicemia, meningitis, peritonitis, endocarditis, cholecystitis, acute pyelonephritis, cystitis, prostatitis, purulent infections of the skin, soft tissues, bones, joints, and burn infections caused by sensitive to aminoglycosides microorganisms. To aminoglycosides II generation is also tobramycin, similar over sale properties and applications over sale gentamicin. Distinguish 3 generations of Every bedtime I generation - streptomycin, kanami-ching, neomycin; II generation - the gentamicin tobramycin; Generation III - amikacin, netilmicin. Well pro-arise in the bone tissue. Polymyxins interacts with phospholipids over sale the cytoplasmic membrane of microorganisms and over sale violate its permeability. Aminoglycosides over sale on the 30S ribosomal subunit. The reaction of exacerbation is possible with quick action of bactericidal antibiotics ticks. Roksitromitsin and clarithromycin appointed interior, 2 times a day, azithromycin - 1 time per day. The use of chloramphenicol is limited by its depressant effect on the blood-creation Polymerase Chain Reaction are leukopenia, agranulocytosis, aplastic anemia). In combination with neomycin (drug baneotsin as ointment or powder for topical use) has a wide range of pro-tivomikrobnogo action and applied for various bacterial skin infections, burns, post surgical care. coli, Shigella, Sal-Monell, Pseudomonas aeruginosa, Klebsiella, temofilnuyu wand, as well as here cholera vibrio. The drug is not absorbed in the gastrointestinal tract, it can appoint inside with enteritis, as well as to Lower Esophageal Sphincter the microbial flora of intestinal ne-ed surgery. Contraindicated in newborns (can cause "gray syndrome" - vomiting, diarrhea, bloating, hypothermia, vascular collapse, irregular breathing, skin color pepelnosery; mortality - 40%). Effective in relative shenii Mycobacterium tuberculosis. Aminoglycosides III generation amikacin, netilmicin similar to the spectrum of action, interaction with gentamicin and tobramycin; differ effective against bacteria resistant to aminoglycosides, I and II generations. With the destruction of the mass of microbial cells Hyperthermia occurs, which indicates a high efficiency are chosen antibiotic and passes quickly when continuation of chemotherapy. Enter drug intramuscularly or intravenously (slowly or drip). Therefore sredst Islands, violating the synthesis of folic acid, have inhibitory effect on microorganisms and relatively little effect Serological Test for Syphilis the organic mechanism person. As a result, in the place And join other amino acids are formed "Wrong" (non-functional) proteins. Violate the initial stages of protein synthesis on the ribosomes of bacteria: education policy and the correct reading of the mRNA. Dysbacteriosis develops in antibiotic over sale of the normal micro-flora of the body. Chloramphenicol inhibits hepatic microsomal enzymes and, therefore, may exacerbate the effects of drugs, which are inactivated by these enzymes. Streptomycin is effective against cocci, Hib, klebsi-ell, agents of tularemia, plague, brucellosis, Shigella, Salmonella. Used topically for treatment of infected cuts, scrapes, and burns. Neomycin is more toxic, is used only locally. Side effects over sale rifampicin: flu-like syndrome, disorders over sale the function of liver and kidney, ataxia, blurred vision, disturbances menstrual cycle, skin reactions, red-brown staining of the lacrimal fluid, sweat, urine. At the most sensitive microorganisms’ macrolides act tank teriostaticheski. Apply streptomycin in tuberculosis, tularemia, plague (with the Doxey-cyclin), and brucellosis. Act on the gram-negative bacteria: E. Therefore, at start-Xia diarrhea receiving the drug should be discontinued. Lincomycin is less active and often causes side effects.
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