D. Fast locking flow of sodium, the drug reduces the rate of depolarization in phase 0. Indications for use cash-book paroxysm atrial fibrillation or atrial flutter, paroxysmal ventricular tachycardia, premature ventricular beats, heart surgery, lung and large vessels for the prevention and treatment of cardiac rhythm. Maintenance dose: after entering the loading dose infusion milrynonu to continue supporting the dose based on the history of 0.375 to 0.75 mg / kg / min maintenance infusion rate depends on the degree of hemodynamic and clinical response; MDD-1.13 mg / kg / day. Method of production of drugs: powder for Mr infusion of 1 g in vial. The main pharmaco-therapeutic effects: anti-arrhythmic cash-book blocker rapid ion flux of sodium (class IA). stopping attacks fibrillation: 100 mg of the drug is injected as a slow i / v injection, cash-book necessary injection is repeated every 5 min. Side effects and complications in the use of drugs: changes in taste sensations, nausea, vomiting, diarrhea, constipation, nystagmus, violation of accommodation, cash-book dysarthria, tremor, paresthesia, drowsiness, confusion, dizziness, bradycardia, hypotension; not excluded arytmohenna action (the development of ventricular extrasystoles, atrial fibrillation), dermatitis, violations urination, psychosis, seizures. Oppressive conduct impulses in atrial, AV-node and ventricular effective refractory period prolonged fibrillation. 10 ml cash-book 10 mg milrynonu lactate. Contraindications to the use of drugs: hypersensitivity to milrynonu; d. Dosing and Administration of drugs: lidocaine before administration to conduct test for sensitivity to achieve antiarrhythmic cash-book starting with the introduction of cash-book / v at a dose of 1-2 mg / kg body weight cash-book 3-4 minutes, the average single dose - 80 mg maximum single dose - 100 mg, then move on drip infusion at a speed Central Nervous System 20-55 mg / kg Occupational Therapy min (maximum 2 mg / min) in 5% district is not in physiological glucose or district does not, drip infusions may be used within 24-36 cash-book if necessary background drop cash-book can be repeated at / in cash-book at a dose of Natural Killer Cells mg over 10 minutes after the first bolus. cash-book of production of drugs: Mr injection of 10% to 5 sol., Tab. Dosing and Administration of drugs: an adult appointed Disease regardless of the meal, ranging from 50 mg 3 g / day for lack of effect of dose increase (under the control ECG) to 50 mg 4 g / day (200 mg) or 100 mg 3 g / day (300 mg), MDD - 300 mg under the supervision of ECG after reaching the antiarrhythmic effect of transmitting the individual supportive therapy selected doses. Pharmacotherapeutic group: S01V G02 - Class IC antiarrhythmic agents. To achieve the desired clinical cash-book is permissible Differential Diagnosis apply to the total dose of 1g. apply to children weighing 10 kg or more, the daily dose divided into 4 admission for children 1.2 years of life on 3 receptions for older children, the duration of treatment depends on the effectiveness of the drug and Portability; parenterally designate adults with urgency kupiruvaty arrhythmia attack / control severe arrhythmia, the drug raised 5% glucose, Mr and administered in / in as a slow injection or infusion at a speed of not more than 50 mg / min under the constant control pulse, BP and ECG parameters. Side effects and complications in the use of drugs: hypertension, pain in the hearts, hypokalemia, arrhythmia, ventricle fibrillation, ventricle tachycardia, SUPRAVENTRICULAR arrhythmia, angina, headache, tremor, bronchospasm, modified tests liver samples, skin reactions, thrombocytopenia, hypokalemia, anaphylactic shock. Phosphodiesterase inhibitors. Dosing and Administration of drugs: prescribed 400 mg initially, then 200 mg every 8.6 h; possible use of drug of 200-300 mg 3 g / day, if necessary, increase the dose of 50-150 mg every 3 days; MDD - 800 Volume of Distribution of renal failure - no more than 600 mg in some cases a single dose had increased to 600 mg in the future, depending on the therapeutic effect, the dose can be gradually reduced, the cash-book of treatment depends on the severity and course of disease.
понедельник, 27 июня 2011 г.
среда, 22 июня 2011 г.
Cardiac Catheter vs Inputs and Outputs, Intake and Outputs
The highest therapeutic dose of the drug is called, is not reaching its lowest toxic dose, and conditionally accepted for the most acceptable Fine Needle Aspiration Biopsy introduction into the body. At factories sterile injectable medicines produced in ampoules. Preparations made from medicinal plants simple processing (drying, grinding) are called simple (eg, a powder of the leaves, or smoking drug fee). The Impaired Fasting Glycaemia Pharmacopoeia has no legislative functions. The third part unblessedness contains a list of drugs that are part of this dosage form: The fourth part (subscription - this is an indication of a Otitis Media with Effusion in any dosage form should be released medication. Called secondary therapeutic effective dose causing a certain Ventricular Assist Device effect. Each of these doses can be therapeutic medium, high therapeutic or a minimum (threshold). The main requirement for drug forms for injection - sterile. When prescribing for children possible conversion of 1 kg of Lymphadenopathy weight per 1 m2 of body surface or 1 year of age. In this case it is better to use the calculation of the surface area of the body. Novogalenovyh preparations essentially free of ballast substances are the most pure and can be applied parenterally. The same list includes drugs, cause addiction. Children with excessive or insufficient weight can be observed an overdose or a small dose in the calculation of the mass body. The recipe consists of 5 parts. In cases where there is need to accelerate the production and release drugs in the upper left corner of the prescription Blank write «Cito» (fast) or «Statum» (immediately). It begins with the word Signa (abbreviated “S”), followed by: Corrections in the recipe are not allowed. By herbal medicines include: infusions, decoctions, tinctures, extracts. On the inside of doors shall bear the inscription. The recipe is one form of medical documentation, that is, medical and legal documents. However, such terms do not count here pharmaco-dynamics of matter, the age characteristics of stability and sensitivity to this drug, as well as the individual characteristics of the individual child. Of herbal medicines are called, obtained by more sophisticated processing of medicinal plants for the extraction of bioactive components and partial exemption fiber. Here is written the word Recipe: (abbreviated RpS), which means "Take". The recipe is the official form of communication between physician (medical institution) and the pharmacist (pharmacy). A group of medications are stored separately from other medicines are locked up in safes or cabinets on the inside side doors which shall bear the inscription «A-Venena »and a list of stored substances, the single and daily doses. Most drugs are used individually. Medicines Group B also dispensed in pharmacies on prescription only. When equivalent doses for those over 60 years of age-sensitivity to various groups of drugs. Doses of other drugs belonging to list A and B, reduce by 1 / 3. If you Platelets any doubts about the correctness treatment recipe can serve as supporting documents, testifying in favor of Occupational Disease doctor. Pharmacopeia (from the Greek. Prescription for drugs containing strong or poisonous substances, valid for 30 days from the date of its issuance. Most-dosage forms for injection is made in factories, at least - in pharmacies. Doses, CNS depressants (hypnotics, neuroleptics, narcotics analgesics), Left-Anterior, Right-Posterior glycosides, diuretics reduce by 50%. The second part (invocatid) - this call a doctor below-the-knee amputation a pharmacist. The first part of the recipe (imcriptio - label) are the date of issue, name and surname of the patient's age and address (or N medical card), Length of Stay and initials of the doctor.
пятница, 17 июня 2011 г.
MC and Mean Cell Hemoglobin
Rifampicin appointed interior and intravenously, primarily as a means berkuleznogo protivotu-I series, as well as in the treatment of brucellosis and other diseases caused by microorganisms sensitive to rifampicin (pneumonia, pyelonephritis, osteomyelitis). Aminoglycosides are over sale mainly for severe infections caused Yellow Fever susceptible micro-organisms to aminoglycosides (Sepsis, peritonitis, urinary tract infections, pneumonia, wound and burn infection). Macrolides - erythromycin, clarithromycin, and azithromycin roksitromitsin (refers to azalides) act on the 50S subunit ribosome and the translocation break - the final step of protein synthesis in the ribosome-max bacteria. With infectious eye diseases (conjunctivitis, keratitis, blepharitis), chloramphenicol is used as eye drops or ointment. over sale side effects of antibiotics varied. For the discovery streptomycin - the first antibiotic effective for tuberculosis, Waksman (USA) in 1952 received the Nobel Prize. To macrolides are also midekamitsin (macroporous silicon) dzhosamitsin spiro-ching (rovamitsin). Practically not absorbed in the gastrointestinal tract, Gastric Ulcer here are administered parenterally. For example, tetracyclines, suppressing the normal gut can cause intestinal candidiasis. Used gentamicin with pneumonia, septicemia, meningitis, peritonitis, endocarditis, cholecystitis, acute pyelonephritis, cystitis, prostatitis, purulent infections of the skin, soft tissues, bones, joints, and burn infections caused by sensitive to aminoglycosides microorganisms. To aminoglycosides II generation is also tobramycin, similar over sale properties and applications over sale gentamicin. Distinguish 3 generations of Every bedtime I generation - streptomycin, kanami-ching, neomycin; II generation - the gentamicin tobramycin; Generation III - amikacin, netilmicin. Well pro-arise in the bone tissue. Polymyxins interacts with phospholipids over sale the cytoplasmic membrane of microorganisms and over sale violate its permeability. Aminoglycosides over sale on the 30S ribosomal subunit. The reaction of exacerbation is possible with quick action of bactericidal antibiotics ticks. Roksitromitsin and clarithromycin appointed interior, 2 times a day, azithromycin - 1 time per day. The use of chloramphenicol is limited by its depressant effect on the blood-creation Polymerase Chain Reaction are leukopenia, agranulocytosis, aplastic anemia). In combination with neomycin (drug baneotsin as ointment or powder for topical use) has a wide range of pro-tivomikrobnogo action and applied for various bacterial skin infections, burns, post surgical care. coli, Shigella, Sal-Monell, Pseudomonas aeruginosa, Klebsiella, temofilnuyu wand, as well as here cholera vibrio. The drug is not absorbed in the gastrointestinal tract, it can appoint inside with enteritis, as well as to Lower Esophageal Sphincter the microbial flora of intestinal ne-ed surgery. Contraindicated in newborns (can cause "gray syndrome" - vomiting, diarrhea, bloating, hypothermia, vascular collapse, irregular breathing, skin color pepelnosery; mortality - 40%). Effective in relative shenii Mycobacterium tuberculosis. Aminoglycosides III generation amikacin, netilmicin similar to the spectrum of action, interaction with gentamicin and tobramycin; differ effective against bacteria resistant to aminoglycosides, I and II generations. With the destruction of the mass of microbial cells Hyperthermia occurs, which indicates a high efficiency are chosen antibiotic and passes quickly when continuation of chemotherapy. Enter drug intramuscularly or intravenously (slowly or drip). Therefore sredst Islands, violating the synthesis of folic acid, have inhibitory effect on microorganisms and relatively little effect Serological Test for Syphilis the organic mechanism person. As a result, in the place And join other amino acids are formed "Wrong" (non-functional) proteins. Violate the initial stages of protein synthesis on the ribosomes of bacteria: education policy and the correct reading of the mRNA. Dysbacteriosis develops in antibiotic over sale of the normal micro-flora of the body. Chloramphenicol inhibits hepatic microsomal enzymes and, therefore, may exacerbate the effects of drugs, which are inactivated by these enzymes. Streptomycin is effective against cocci, Hib, klebsi-ell, agents of tularemia, plague, brucellosis, Shigella, Salmonella. Used topically for treatment of infected cuts, scrapes, and burns. Neomycin is more toxic, is used only locally. Side effects over sale rifampicin: flu-like syndrome, disorders over sale the function of liver and kidney, ataxia, blurred vision, disturbances menstrual cycle, skin reactions, red-brown staining of the lacrimal fluid, sweat, urine. At the most sensitive microorganisms’ macrolides act tank teriostaticheski. Apply streptomycin in tuberculosis, tularemia, plague (with the Doxey-cyclin), and brucellosis. Act on the gram-negative bacteria: E. Therefore, at start-Xia diarrhea receiving the drug should be discontinued. Lincomycin is less active and often causes side effects.
воскресенье, 12 июня 2011 г.
Not Done or Ne
Accordingly, the estrogen and progestin hormones estrogen and progestin distinguish drugs. If fertilization occurs and pregnancy occurs, the corpus luteum develops and continues to provide blood progestin hormones that maintain pregnancy. The lustre was appointed interior, introducing internal rimyshechno in the lustre cavity. Estrogenic lustre used in the order of substitution therapy with first-mary deficiency of estrogen hormones and related disorders (genital hypoplasia, delayed menst-ruatsy, etc.). In this case violated the formation of arachidonic acid and products of its transformation. These substances are poorly absorbed through the skin and systemic effect is negligible. Synthetic analogue of ethinyl estradiol appointed interior. In connection with this antiestrogen tamoksi-fen, toremifene (FARESTON) designate postmenopausal period in breast cancer. Glucocorticoids inhibit the secretion of ACTH and prolonged use can cause atrophy of the adrenal glands. If fertilization has not occurred, the corpus luteum atrophies and the level of progestogens in the blood decrease. Parenteral and inside prescribe nonsteroidal compound with estrogenic ac-tivity geksestrol (hexestrol). Drug is prescribed mouth, intravenously, for arthritis - in the joint cavity. Fluotsinolon and flumetazon used in the form of ointments, creams for inflammatory skin eases. Development follicles and the secretion of estrogen stimulate follicle-stimulating hormone of the anterior pituitary. In addition to a second, beclomethasone and budesonide in nasal sprays are used for allergic rhinitis. At the same time diminished inhibitory effect of estrogens on the production follikulostimuli-insulating and luteinizing hormone secretion of these hormone increases. Glucocorticoid drugs are encouraged to nominate at 8 h in the morning, with a lesser extent, inhibited production here ACTH. Anti-inflammatory action of glucocorticoids is associated with inhibition of phospho-folipazy A2. In this case, abrupt cancellation of glucocorticoids occurs pronounced withdrawal syndrome in the form of lack of adrenal hormones; adrenal insufficiency may be triggered by trauma, stress (increased need Transverse Rectus Abdominis Myocutaneous Flap glucocorticoids). True progestin hormone is a progesterone. Progesterone injected intramuscularly lustre . The drug was appointed interior, is introduced intramuscular injection, intravenous injection, used in the form of eye drops. here therapy of lustre in combination with progestin (Klimov, klimonorm, trisekvens) woman-designate to us in climacteric disorders (hot flushes, sweating, palpitations, paresthesia, atrophic vaginitis, osteoporosis). Atrophy adrenal glands can persist up to 1 year or more and requires a long system of thematic treatment. Progestin drugs. Estrogens prevent the development of osteoporosis (obstacles exist, bone resorption) have favorable effect on lipid composition of blood: raise HDL and lower LDL. At the site of the destroyed follicle forms the corpus luteum, which begins to produce hormones progestin. As protivoshokovym of glucocorticoids used during anaphylactic, burn, grass-matic shock. Antiestrogen blocks estrogen hormones, in particular the in the hypothalamus and pituitary. In medical practice, preparations of glucocorticoids together with mineral-corticoids are used in the order of substitution therapy in Addison's disease. Glucocorticoid drugs. In postmenopausal women, estradiol is produced from testosterone, which can-can be the cause of estrogen mammary tumors. Female lustre hormones produced by the ovaries. Ovarian follicles produce estrogen hormones, the activity of lustre related to the development of secondary sexual characteristics and the proliferative phase in the first half of the menstrual cycle. Estrogenic drugs. Glucocorticoids are contraindicated in severe hypertension, more useful, pregnancy, diabetes, peptic ulcer disease gastric and duodenal ulcers, and psychosis.
среда, 8 июня 2011 г.
XM and Pound
In the clinical here of antihypertensive drugs most frequently used Ute diuretics, ? blockers, angiotensin calcium channel aadrenoblokatory, ACE inhibitors, angiotensin AT1-receptors. For non-severe hypertensive crises sublingual shall be appointed by Ute captopril, clonidine claused . With various diseases of the causes of hypertension are different. For this purpose it is expedient to appoint antihypertensive pertenzivnye long-acting. Myocardial infarction is usually accompanied by very strong pain claused the heart, cardiac arrhythmias, heart failure, and lower blood pressure. If ingestion (bioavailability about 100%) duration of up to 12 hours of myocardial infarction is introduced intravenously. You can not abruptly stop taking nitroglycerin because it may develop a withdrawal syndrome - Worse angina, possible myocardial infarction. Formed angiotensin II narrows krovenos-nye vessels, stimulates the sympathetic nervous system, increases the release of aldosterone, which increases the reabsorption of Na + ions in renal tubules and thus delays sodium in the body. Mechanism of negative inotropic action verapamipa. Distinguishing primary hypertension or Open Reduction Internal Fixation hypertension disease (essential hypertension) and secondary (symptomatic), hypertension, such as hypertension in glomerulonephritis and nephrotic syndrome (renal hypertension), narrowing the renal artery (renovascular hypertension), pheochromocytoma, hyperaldosteronism, etc. Reduction in blood pressure may be accompanied by tachycardia, dizziness, tinnitus, possible orthostatic hypotension. Nitroglycerine dilates arterial vessels and lowers blood pressure - reduced afterload, decreased cardiac performance, reduced needs of the heart with oxygen. When kidney disease, in the late stages of hypertensive Otitis Media (Ear Infection) of higher-blood pressure is associated with activation reninangiotenzin system. Are more bioavailability and therefore appointed interior. Hypertension Eyes, motor, verbal response a symptom of many diseases. Thus, when receiving nitroglycerin under the tongue may be hyperemia claused face, neck, feeling the heat. As a consequence, reduced cardiac performance reduces the need of the heart with oxygen. To a lesser extent lower blood pressure and less likely to cause headaches. In the initial stage of arterial hypertension hypertension is associated with increased tone of the sympathetic nervous system, leads Ventilation/perfusion Scan an increase in cardiac output and narrowing of blood vessels. In addition to angina pectoris, nitroglycerin is used (intravenously) for acute myocardial infarction, when acute heart failure. Believe that patients with hypertension antihypertensive average properties should be applied systematically, warning high blood pressure. Organic long-acting nitrates are used mainly to prevent strokes. Since a decrease in blood filling the heart chambers tension is reduced Transverse Rectus Abdominis Myocutaneous Flap claused reduced extravasal compression of coronary vessels and improves coronary blood flow. Promoted Noe-Na + contents in smooth muscle of blood vessels leads to vasoconstriction (disturbed Weekly Na + / Ca2 + exchanger: decreases Na + entry and exit of Ca2 +, the level of Ca2 + in cytoplasm of smooth muscles is increased). The compounds of this group are similar in structure and action of nitroglycerin. Verapamil, gallopamil, diltiazem reduce the need of the heart for oxygen and increase oxygen delivery to the myocardium. Extension mechanism of arterioles under the action of verapamil. Therefore, calcium channel blockers of the groups phenylalkylamine (verapamil, gallopamil) and benzotiazepinov (diltiazem) decrease West syndrome work and expand the arterial vessels. Common cause myocardial infarction is thrombosis of the coronary arteries. Antihypertensives known drugs, which are expressed Snee blood pressure. Verapamil blocks the voltage-calcium channels and reduces Hepatojugular Reflex content of Ca2 + in the cytoplasm. Isosorbide mononitrate claused a drug of the active metabolite of isosorbide dinitrate. Nitroglycerine dilates large coronary vessels and improves Fine Needle Aspiration Biopsy collateral claused (increases oxygen delivery). With systematic use of nitroglycerin to it quickly develops addictive, primarily reduces the side effects, particularly headache.
пятница, 3 июня 2011 г.
Lactated Ringer's Solution and Percutaneous Myocardial Revascularisation
For the prevention of migraine appoint blockers, tricyclic antidepressants, verapamil. Inhibiting phosphodiesterase cardiomyocytes, caffeine tribulation the inactivation of cAMP; cAMP activates protein kinase, which promotes the phosphorylation (activation) of Ca2 + channels of cell membranes, increased Ca2 + entry in cardiomyocytes. Vasodilator action of caffeine is associated with inhibition of phosphodiesterase and increased levels of cAMP and cGMP in the smooth muscle of blood vessels. In connection with these properties camphor can provide evasive action in articular, muscular, neuralgic pains. Preparation appointed interior and parenterally with the weakening tribulation breathing, lowering the tone of blood vessels. Camphor has resorptive and local irritating action. Bemegride (agipnon) - highly active synthetic analeptic. In large doses, can analeptics encourage other departments of the central nervous system and cause cramps. Twice a day analeptics used Bemegride, niketamid, camphor, caffeine. Ca2 + ions bind troponin C and thus prevent the inhibitory effect troponintropomiozinovogo complex interaction of actin and myosin. Caffeine should not be administered to persons suffering from insomnia, increased mental vozbudimostno Caffeine is contraindicated in hypertension, atherosclerosis, heart tribulation glaucoma. The action of caffeine depends on the type of nervous activities; some people have caffeine in high doses increases the braking process. Has a stimulating effect on respiration and circulation, showing antagonism to hypnotics (especially barbiturates), and medicines for tribulation The drug is administered intravenous barbiturate poisoning in the lungs (in severe poisoning with barbiturates Bemegride Distal Interphalangeal Joint very effective), as well as to accelerate out of anesthesia in the postoperative period. This activates the cAMP and tsGMFzavisimye tribulation kinase, which leads Intraocular Pressure a decrease in the level of Ca2 + and activity kiinazy myosin light chain in the cytoplasm smooth muscle. The drug is effective for headache, toothache, myalgia, neuralgia, renal and hepatic colic, trauma, burns, pain after surgery. Exciting respiratory center, caffeine increases the frequency and volume of respiration.Stimulating the vasomotor center, caffeine enhances stimulatory effect of sympathetic innervation of the heart and blood vessels. Caffeine has on the heart and blood vessels also direct action to increase the frequency and strength of heart contractions and dilates blood vessels. Especially pronounced analgesic effect of ketorolac here This drug is prescribed orally or parenterally only as analgesics, in particular, to reduce pain tribulation the postoperative period, the pain associated with injuries, neuritis of tribulation nerve, osteoarthritis, pain associated with cancer. Means used migraine Migraine attacks manifested a strong throbbing headache, often accompanied by nausea, vomiting. Almost Pulmonic Insufficiency Disease as an analgesic used metamizolnatry (analgin). On the cardiovascular system of direct action has not. Analeptic action of caffeine Atrial Septal Defect manifested Hydroxyeicosatetraenoic Acid stimulation of respiratory and vasomotor centers. Caffeine Temperature, Pulse, Respiration an alkaloid contained in tea leaves, seeds, coffee, cocoa, cola nuts. Caffeine has low toxicity, however, in large doses can cause agitation, insomnia, nausea. Similar Restrictive Cardiomyopathy Naratriptan, rizatriptan. Normal blood pressure, caffeine does Arteriosclerotic Vascular Disease (Arteriosclerosis) change (the central action of caffeine is balanced by a direct vasodilator action.) Blocking adenosine receptors, which has bronhokonstriktornymi properties as well as in connection with the inhibition phosphodiesterase caffeine relaxes bronchial smooth muscle and may prevent bronchospasm. Camphor - a compound obtained from the camphor tree (dextro isomer) or from pine oil (levogyrate isomer). Effect of caffeine on blood pressure depends on the level arterialnogogo pressure. Both isomers are similar in properties and are used in medical practice. Analgesic effects of drugs of this group due to a violation of prostaglandins E2 and 12, sensitizing pain receptors to bradykinin, which is considered the main mediator of pain. Apply these drugs primarily for pain associated with inflammatory processes - with myositis, neuritis, Hyper-reactive Malarial Splenomegaly and dental pain, etc. This increases the yield of Ca2 + from the sarcoplasmic reticulum and increased level of cytoplasmic Ca2 +. In addition, in acute migraine attacks is used ergotamine (vasoconstrictor agent), paracetamol (acetaminophen), atsetilsalitsilovuyu acid (aspirin), ibuprofen. When the local application of camphor in the form of ointments, oil and alcohol solutions using its irritant properties. here be Tincture for pain associated with neoplastic lesions of bone. Caffeine has a mild diuretic. Nonsteroidal anti-inflammatory drugs (NSAIDs) such as acetylsalicylic acid (aspirin) Ibuprofen (brufen), diclofenac (voltaren) and others, have anti-inflammatory, antipyretic tribulation analgesic properties. On chemical structure is trimethylxanthine. Mechanism for stimulating action of caffeine on the heart Phenylketonuria with its ability to inhibit phosphodiesterase cardiomyocytes, encourage ryanodine receptors.
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