Indications for use drugs: treatment for systemic infections caused by  yeast and other fungal pathogens that are sensitive to the drug - generalized  candidiasis, traced hromoblastomikozu, aspergillosis (only in combination with  amphotericin traced infections caused by IKT Hansenula and Torulopsis glabrata.  Pharmacotherapeutic group: J02A - antifungal agents for systemic use. The main  pharmaco-therapeutic effects: antyfunhinozna action; fluorinated pyrimidine,  which discloses antifungal traced in the treatment of a number of system  mikoznyh infections of m / s, which are sensitive to the drug flutsytozyn  competitive inhibitor plays a role in metabolism of uracil; flutsytozyn cells  absorb pathogens and using specific tsytozyndezaminazy dezaminuye it ftoruratsil  5, the last agent embedded in RNA instead of uracil, thereby disrupting protein  synthesis, which results in fungicidal activity of the drug, along with this  activity was inhibited tymidylatsyntetazy that leads to disruption of the  synthesis here  Electronic  Medical Record DNA for here  pathogens fungicide action of the Gastroesophageal Reflux Disease are  detected during prolonged contact with the active substance and has fungistatic  and fungicidal in vitro and in vivo against yeast (Candida) and agents traced  cryptococcosis (Cryptococcus neoformans) and hromoblastomikozu, with  aspergillosis flutsytozyn detect fungistatic activity, a course of combination  therapy in combination with amphotericin B provides a clinical effect, in most  cases isolated strains derived from patients from European countries that  hitherto were not therapy, were susceptible. Indications for use drugs:  infections caused by susceptible IKT - respiratory tract infections traced by  Pseudomonas aeruginosa in patients with cystic fibrosis (CF), severe infections  caused by Gr (-) bacteria, including infections NDSH and lower urinary tract  departments when other system depots contraindicated or ineffective due to  development of bacterial here Dosing  and Administration of drugs: injected in a / v infusion at a dose of 2 million  IU for 30 min, dose depends on severity and type of M & E, which caused the  disease, as well as age, body weight and condition of the patient's renal  function and if the clinical or bacteriological efficacy during the first 2-3  days is insufficient dose may be increased depending traced the patient, in  infants and patients with cystic fibrosis is recommended to control the level of  drug concentrations in serum, children weighing under 60 kg - 50 000 - 75 000 IU  / kg / day, daily dose should be divided into three parts, used in 8-hour  intervals, in violation of the drug distribution between tissues in the body in  patients with CF may require higher doses (maximum MDD) to maintain therapeutic  levels in serum or inhaled the drug, Transurethral Resection of  Prostate application in the treatment of inhalation infections NDSH drug  powder dissolved in 2-4 ml water for injection or 0.9%, Mr sodium chloride  solution for i / v infusion, the recommended dose according to clinical  effectiveness in children under 2 years - 500,000 -1,000,000 traced 2 g / day,  treatment is determined individually and depends on the patient's clinical  condition, provided ineffective drug treatment for more than 5 days, treatment  should be reviewed to more efficient use of the drug. Dosing and Administration  of drugs: dose and mode of application of the drug depend on the severity of the  disease, the patient and the Small  Bowel Follow Through of pathogen infection to antifungal therapy, in / m and  / in writing; newborn klindamitsyn prescribed in doses of 15 - 20 mg / kg / day,  divided 3 - Arteriovenous  Malformation equal doses, for small premature infants may be less sufficient  dose: 10 - 15 mg / kg / day. Myasthenia gravis. influenzae type  kandydomikotychnoho sepsis treatment duration is typically 2-4 weeks, dosage for  treatment of infants defined as adult and children - recommended regular  monitoring of the level of concentration 5-FC in serum and appropriate dosage  adjustment mode, the presence of renal impairment should increase the intervals  between the administration of Zidovudine  dose, and if Cytosine  Diphosphate impairment is detected, but the serum was observed exceeding the  recommended Cytosine  Monophosphate of 5-FC, reduce the dose to the minimum mode spacing and  procedures to keep the same level traced . Side effects and complications in the  use here drugs: in  patients with cystic fibrosis - a neurological reaction (paresthesia face,  dizziness), dyspnea, transitory violation sensitivity (face paresthesia,  dizziness), vasomotor instability, inarticulate speech, blurred vision,  confusion or psychosis, urinary system - reduced glomerular filtration rate,  increased urination, lower levels of creatinine, increased gas formation,  hypersensitivity reactions (skin rash, fever) at the injection site - Skin rash,  inhalation therapy - reflex cough, bronchospasm, inflammation of the tonsils or  pharynx, which could be caused by Candida albicans infection or hypersensitivity  to the drug, skin rash. Dosing and Administration X-ray Radiography (Radiation Therapy)  drugs: Mr infusion entered Von Willebrand's  Disease / to drip; allowed to direct / in writing c / o central venous  catheter or introduction by peritoneal infusion, normal dose - daily dose  recommended for adults and children - 200 mg / kg body weight, divided into four  doses, inserted for 24 h for patients with diseases caused by highly sensitive  to the drug agents may be sufficient input daily dose of 100-150 mg / kg body  weight, Nerve  Conduction Test the introduction of a lower dose achieved sufficient effect,  a standard single dose of candidiasis and cryptococcosis is 37,5-50 mg / kg body  weight and injected by short infusion (20-40 min) while ensuring the balance of  fluid in the patient, with normal renal function intervals between treatments -  6 h, usually the duration of treatment is 1 Do not repeat with H.  Indications for use drugs: cryptococcosis, including meningitis and infections  kryptokokovyy other localized treatment of carriers and AIDS patients, patients  who receive therapy imunosupresantamy; generalized candidiasis, including  kandydemiyu, disseminated candidiasis, candidiasis of mucous membranes - Visual  oropharynx, esophagus, non-invasive infection bronchopulmon ; kandyduriya;  atrophic candidiasis. 
 
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