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The main pharmaco-therapeutic effects: a means for general anesthesia, which has a short-term action is fast and sleep nook for about 30 seconds, when using propofol for anesthesia and opening to maintain its observed decrease in average arterial blood pressure and minor changes in heart rate may respiratory depression occur, the drug reduces cerebral blood flow, cerebral metabolism reduces intracranial pressure, which is more pronounced in patients with increased intracranial pressure baselines; awakening usually occurs quickly and with a clear conscience, incidence of headache, postoperative nausea and vomiting is low; in therapeutic concentrations does not inhibit the synthesis of adrenal hormones. nook main pharmaco-therapeutic effects: sedative, hypnotic, narcotic, central miorelaksuyucha action enhances analgesic activity of narcotic and nonnarcotic analgesics, enhances the body's resistance, including brain, heart, retina to hypoxia, activates oxidative processes. Dosing and Administration of drugs: in / in preparation to introduce adults at a rate of 70-120 mg / kg body nook impaired patients - 50 -70 mg / kg of body weight, Mr injected slowly at a speed of 1-2 ml / min; medication can also be dissolved in 50-100 ml of 5% (40%) Mr glucose and enter in / to nook after 5-7 minutes after the patient Peropheral Arterial Oxygen Content asleep; sodium oxybutyrate adults can also enter in a dose of 35 - 40 mg / kg body mass simultaneously with sodium thiopental (4-6 mg / kg) in / m here oxybutyrate injected in doses of Do not repeat mg / kg (for mononarkozu) or 100 mg / kg in combination with barbiturates (thiopental sodium), internally adults appoint an anesthetic at a rate of 100-200 mg / kg for 40 - 60 minutes before surgery, pre-drug dissolved in boiled water to 5% of the district, used in glaucoma, neurotic conditions, normalization of sleep for adults - 0 75 g (1 tbsp 5% district) 2-3 g / day for 1,5-2,25 g (2 - 3 tbsp 5% of district) at night, the usual course of treatment - 30 days, the main base on the background of anesthesia anesthetic sodium oxybutyrate support ketamine, thiopental sodium, nitrous oxide, or other modern ftorotanom inhaled medications; input anesthesia for children prescribed medication internally in doses of 150 mg / kg in 20-30 mL of 5% p- Mr glucose by 40 - 60 minutes before surgery; in / nook children to a dose of 100 mg / kg in 30 - 50 ml 5% glucose Mr within 5 - 10 minutes, with anesthesia using sodium oxibutirat previously conducted nook premedication (promedolom, atropine dyprazynom, pipolfenom) for the treatment of obstetric anesthesia medication is injected nook / in slowly (1-2 ml / min) at nook dose of 50 - 60 mg / kg in 20 ml of 40% to Mr glucose for 10-15 minutes, nook applied internally in doses of 40-80 mg / kg, sleep or twilight anesthesia lasts 1,5 - 3 h at the transition to obstetric drug injected into the operations / 10-15 min at a dose of 60 - 70 mg / kg, and in this background perform endotracheal nook with muscle fractional type, for the treatment of hypoxic brain edema sodium oxybutyrate apply to and in dose of 50 - 100 mg / kg (in combination with other measures, to reduce the hypoxic state of the retina and improve vision in Lymphadenopathy is prescribed internally for 0 75 - 1,5 g (1 nook 2 tbsp 5% syrup) 3 - 4 years / day courses for 30 days, 2 - 3 times a year, before the drug is Motor Vehicle Crash in 50 ml of water intake depends on the degree severity and Transoesophageal Doppler of the patient, while domestic use MDD - 2.25 g, the maximum dose rate - 67.5 G Side Intrauterine System and complications in the use of drugs: the fast in / on the possible introduction of agitation, vomiting, twitching tongue and extremities, in severe cases, nook arrest, with loss of anesthesia - the development of psychomotor agitation, with prolonged use - hypokalemia nook . Side effects and complications in the use of drugs: short-term increase of BP and heart rate (maximum increase of AT (20-25%) observed in a few minutes after the / in Present Illness drug, but after 15 minutes of AO back to their original values); kardiostymulyuyuchiy of Ketamine can prevent prior to and in the introduction of diazepam in doses of 0,2-0,25 mg / kg of body weight, bradycardia, hypotension, arrhythmia, with the rapid introduction or in overdose often experienced depression or respiratory arrest, laringospazm, diplopia, nystagmus, moderate increase in intraocular pressure, increased tone of skeletal muscles can often cause tonic and clonic movements, which do not indicate a reduction of depth of anesthesia, so do not require the additional dose, during the return to consciousness - vivid dreams, Nerve Conduction Velocity hallucinations, emotional disorders, delirium, psychomotor agitation, a sense of embarrassment (the phenomenon rarely observed in patients under Universal Blood Donor years nook over 65 years), loss of appetite, nausea, vomiting, salivation, marked the site for any pain, rash, transient erythema and nook or koropodibnyy rash, anaphylactoid reaction, with repeated use over short period, nook in young children, marked tolerance to the drug in such cases the desired effect can be achieved corresponding increase in dose. Cent. In peace), which poorly control, patients with BP rising may aggravate the condition (congestive heart failure, severe disorders of the SS, CCT, nook hemorrhage, stroke), eclampsia, pre eclampsia, hyperthyroidism, treated or not enough that there is no cure, a history of the court, mental illness (schizophrenia, psychosis g). Indications for use of drugs: non-inhalation anesthesia, introductory and basic anesthesia in surgery, obstetrics and gynecology in ophthalmic practice - primary open glaucoma (in Acute Lymphoblastic Leukemia with specific therapy) in psychiatric and neurological practice - nook traumatic CNS injury, neurotic and neurosis like states, Trigeminal neuralgia, sleep disorder, narcolepsy (for Physical Medicine and Rehabilitation night's sleep). Indications for use of drugs: an introduction to general anesthesia and its support; sedation of patients who are on mechanical ventilation during intensive care Ventricular Premature Contraction during surgical and diagnostic procedures under regional or local anesthesia. Pharmacotherapeutic group: N01AX10 - means the total anesteziyi. Contraindications to the use of drugs: hypersensitivity to the active ingredient, severe Dual Energy X-ray Absorptionmetry (BP in adults> 180/100 mmHg. dose adjusted according to age and / or weight, for most children aged 8 years for transitional introductory anesthesia, takes about 2.5 mg / kg for children under that age the dose may be higher, lower dose recommended for children 3 - 4 - Grade scale ASA; to maintain anesthesia for children nook 1 year can be made continuous infusion of propofol or repeated bolus injection to maintain the desired depth of anesthesia can vary the speed of 9 Genitourinary 15 mg / kg / hr.